On-virion structural dynamics reveal temperature- and receptor-coordinated activation of an alphacoronavirus spike
Jiaming Liang, Cheng Peng, Y. S. Song, Zheyuan Zhang, Jinfang Yu, Xinquan Wang, Sai Li
This study uses cryo-electron tomography to show temperature and receptor binding coordinate spike protein activation in HCoV-229E virions, revealing structural dynamics and conformational changes.
bioRxiv · Jan 5, 2026 · PreprintMicrobiology