Sai Li

FlyTomo: A streamlined software for on-the-fly cryo-ET data processing and diagnosis

FlyTomo streamlines cryo-ET data processing and diagnosis, enabling real-time feedback and structured data management for improved structural biology research.

Architecture of a portal complex embedded in the poxvirus core

The paper determines the structure of the poxvirus portal complex and its pore, revealing their role in molecular transport and antiviral target potential.

Cryo-ET of IgG bivalent binding on SARS-CoV-2 provides structural basis for antibody avidity

This study uses cryo-ET to examine how two IgGs bind to SARS-CoV-2 S-trimers, revealing structural mechanisms of bivalent binding and antibody avidity.

A Dynamic Oligomerization Network Coordinates Hemagglutinin-Mediated Membrane Fusion on Influenza Virions

The paper determines the in situ structure of prefusion hemagglutinin on influenza virions and shows how HA trimers form cooperative assemblies that coordinate membrane fusion.

On-virion structural dynamics reveal temperature- and receptor-coordinated activation of an alphacoronavirus spike

This study uses cryo-electron tomography to show temperature and receptor binding coordinate spike protein activation in HCoV-229E virions, revealing structural dynamics and conformational changes.

Molecular basis of Ad5-nCoV Vaccine-Induced Immunogenicity

This study investigates the molecular basis of Ad5-nCoV vaccine-induced immunogenicity by analyzing the structure and properties of the spike antigens it induces.

Molecular Architecture of Monkeypox Mature Virus

This study uses cryo-ET and STA to reveal the architecture of mature MPXV particles and identifies irregular virions with distorted core walls.