Zhaoxia Sun

This study shows that inactivating Nphp2 in renal epithelial cells causes nephronophthisis-like phenotypes in mice, including cysts and fibrosis, and that cilia play a role in this process.

This study shows that Hedgehog signaling is non-cell autonomously activated in the interstitium of cystic kidneys in Arl13b mutant mice and that inhibiting this pathway reduces cyst burden and fibrosis.