Carlos A. Paladini

This study identifies subthreshold membrane potential events in midbrain dopamine neurons in vivo, revealing two biophysical mechanisms that generate distinct firing patterns related to prediction error signaling.

This study shows that loss of β-arrestin2 in D2 neurons reduces dopamine inhibition of D2-MSNs and alters behavioral responses to psychostimulants and opioids, while having minimal effect on D1 neurons.

This study shows that VTA astrocytes regulate avoidance behavior by modulating local GABA neuron activity, which inhibits dopamine neurons and blocks reward preference.

This study compares the effects of selective D2 and D3 receptor antagonists on cocaine-induced behaviors in mice, finding opposite modulatory effects on locomotor activity and dopamine signaling.