Author

Jonathan J. Lyons

National Institutes of HealthORCID 0000-0002-2346-8189Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Genetic & Genomic Medicine· 2 Immunology· 1

Signature Assays, Organisms & Methods

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Research Focus:differential expression· 3 Organism:human· 3 Approach:statistical model· 2 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Research Focus:cell-cell communication· 1 Approach:experimental assay· 1 Assay:scRNA-seq· 1

Frequent Co-Authors

Justin LackiD· 2 shared Sarah Camille GloveriD· 2 shared Adam ParkeriD· 1 shared Alex K. ShalekiD· 1 shared Alexander HoischeniD· 1 shared Alexandra K. TurveyiD· 1 shared Ali FouladvandiD· 1 shared Allison MatthewsiD· 1 shared

Activity by Year

2022-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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2 shared papersGenetic & Genomic Medicine

Justin LackORCID

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Author profile →

3 papers

Recent·Most cited

ImmunologyNature ImmunologyPeer-reviewedJan 20, 2025

Impact of variants and vaccination on nasal immunity across three waves of SARS-CoV-2

Jaclyn M. L. Walsh, Vincent N. Miao, Anna H. Owings…·José Ordovás-Montañés

This study examines how SARS-CoV-2 variants and vaccination affect nasal immunity across three waves, identifying changes in cellular states and immune responses.

16 citationstop 1%

humanscRNA-seq

Genetic & Genomic MedicineThe Journal of Experimental MedicinePeer-reviewedFeb 10, 2023

Human Germline Heterozygous Gain-of-Function STAT6 Variants Cause Severe Allergic Disease

Mehul Sharma, Daniel Leung, Mana Momenilandi…·Stuart E. Turvey

This study identifies heterozygous gain-of-function STAT6 variants in two patients with severe allergic disease and shows JAK inhibitors reduce the enhanced STAT6 responses.

125 citationstop 1%

humanstatistical model

Genetic & Genomic MedicineBlood AdvancesPeer-reviewedSep 28, 2022

Genetically determining individualized clinical reference ranges for the biomarker tryptase can limit unnecessary procedures and unmask myeloid neoplasms

Jack F. Chovanec, Ilker Tunc, Jason Hughes…·Jonathan J. Lyons

This study determines individualized tryptase reference ranges by modeling BST levels based on TPSAB1 copy number, showing that elevated levels can indicate clonal myeloid neoplasms or be normal in HT carriers.

62 citationstop 3%

humanbulk RNA-seq