Justin Lack

This study identifies NONO as a host factor that epigenetically regulates DPP4 expression, facilitating MERS-CoV replication by modulating histone modifications at the DPP4 locus.

This study identifies NONO as a critical facilitator of antiviral innate immune response by promoting chromatin accessibility and IFN-I/ISG expression.

This paper develops a human cerebellar organoid model that recapitulates cerebellar development and reveals disease-specific phenotypes in Friedreich's ataxia.

This study uses single-cell RNA sequencing to analyze transcriptional changes in ISE6 tick cells during Ehrlichia muris eauclairensis infection, revealing distinct cell states and time-dependent gene expression patterns.

The paper identifies a PI3Kδ-Foxo1-FasL signaling loop that disrupts Th2 differentiation and epigenetic regulation in CD4+ T cells.

The paper shows that malaria parasites increase clag2 copy number under nutrient stress to enhance host cell permeability and survival.

This study identifies mitochondrial hyperactivity and reactive oxygen species as critical drivers of innate immunity to the YFV-17D vaccine, enhancing IFN response and vaccine effectiveness.

This study shows Jamaican fruit bats can support EBOV replication and shedding but not MARV, due to differences in viral entry and IFN-I signaling suppression.

The paper identifies sphagnum-associated fungi that produce antitubercular agents inducing thiol stress in Mycobacterium tuberculosis.

This study identifies heterozygous gain-of-function STAT6 variants in two patients with severe allergic disease and shows JAK inhibitors reduce the enhanced STAT6 responses.

ImmunoTyper-SR genotypes IGHV alleles from short read data and identifies associations between IGHV alleles and anti-type I IFN autoantibodies in COVID-19 patients.

This study determines individualized tryptase reference ranges by modeling BST levels based on TPSAB1 copy number, showing that elevated levels can indicate clonal myeloid neoplasms or be normal in HT carriers.

The paper establishes reference samples with high-coverage whole-genome sequencing to create truth sets for somatic mutation and germline variant detection using NGS technologies.

This study evaluates reproducibility and accuracy of cancer mutation detection using whole-genome and whole-exome sequencing across multiple sequencing centers and bioinformatics pipelines.