Estimating Gene Prevalence with Incomplete Genomes: Application to the Prochlorococcus Pangenome
Stephen Blaskowski, Louis Goldwater Christie, Yubin Raut, Jed A. Fuhrman, Jacob Bien, E. Virginia Armbrust
The paper develops a maximum-likelihood framework to estimate gene prevalence from incomplete genomes and applies it to Prochlorococcus, revealing a pangenome dominated by rare genes.
bioRxiv · Oct 23, 2026 · PreprintMicrobiology