Jazlyn A. Mooney

Neanderthal introgressed ancestry reveals human genomic regions enriched with recessive deleterious mutations

The paper uses Neanderthal ancestry patterns to identify genomic regions enriched with recessive deleterious mutations using a machine learning classifier.

Genotypic and phenotypic consequences of domestication in dogs

This study uses runs of homozygosity to link genetic diversity with non-disease phenotypes in dogs, finding associations with traits like height, weight, and fur length.

Analytical expectations for ancestry junction accumulation in admixed genomes

The paper develops a model to predict ancestry switches in admixed genomes and validates it against simulations and empirical data.

Reference genome choice compromises population genetic analyses

This study shows that using a conspecific reference genome improves variant detection and genetic diversity estimates compared to heterospecific references in gray foxes.

Towards Simulation Optimization: An Examination of the Impact of Scaling on Coalescent and Forward Simulations

This paper examines how scaling affects coalescent and forward simulations in human and Drosophila populations, finding that scaling impacts diversity estimates, runtime, and selection effects differently in each species.

Recommendations for Population and Individual Diagnostic SNP Selection in Non-Model Species

This paper develops a SNP selection pipeline, mPCRselect, to design cost-effective SNP panels for population assignment and individual identification in non-model species.

Developmental hematopoietic stem cell variation explains clonal hematopoiesis later in life

The paper shows that clonal hematopoiesis later in life is driven by stem cell variation established before birth, using CpG methylation patterns in twins.

Evolutionary consequences of domestication on the selective effects of new amino acid changing mutations in canids

The paper compares the distribution of fitness effects of new amino acid changing mutations between dogs and wolves to assess the impact of domestication on selective pressures.

Chromosome-level assembly of the gray fox (Urocyon cinereoargenteus) confirms the basal loss of PRDM9 in Canidae

The paper presents a chromosome-level genome assembly for the gray fox, confirming the loss of PRDM9 functionality in the basal canid lineage.

The impact of identity-by-descent on fitness and disease in natural and domesticated Canid populations

This study examines how identity-by-descent and inbreeding affect disease and fitness in Canid populations, finding that ROH burden correlates with disease and that breed popularity influences OMIA variant counts.

Understanding the Hidden Complexity of Latin American Population Isolates

The paper analyzes genomic diversity in Latin American population isolates, finding increased genetic diversity and consanguinity compared to the Finnish isolate.