Christian D. Huber

Seasonal fluctuations in fitness result in severe reductions in effective population size

The paper simulates seasonally fluctuating selection in Drosophila populations and shows it reduces genome-wide effective population size by ~50%.

Variation and selection at predicted G-quadruplexes across the human pangenome

The paper analyzes G-quadruplexes across the human pangenome, finding that they show distinct selection patterns and influence gene expression.

Haplotype-based models improve sweep detection in ancient populations with complex demography

This study shows haplotype-based models are more effective than SFS methods for detecting selective sweeps in ancient populations with complex demographics.

Simulations reveal hybridization in Caribbean Acropora restoration poses low risk of genetic swamping but limited potential for adaptive introgression

The paper uses simulations to assess risks and benefits of hybridization in Caribbean coral restoration, finding low genetic swamping risk and limited adaptive introgression potential.

Accessible, realistic genome simulation with selection using stdpopsim

The paper extends the stdpopsim simulation framework to include realistic selection models, enabling studies of selection's impact on genetic variation across species.

Apollo: A comprehensive GPU-powered within-host simulator for viral evolution and infection dynamics across population, tissue, and cell

Apollo simulates within-host viral evolution and infection dynamics, validating limitations of transmission inference tools using HIV cohort data.

The distribution of fitness effects varies phylogenetically across animals

This study examines the distribution of fitness effects (DFE) across eleven animal species, finding that DFE co-varies with phylogeny and that mammals have more deleterious mutations than insects and birds.

Performance of qpAdm-based screens for genetic admixture on admixture-graph-shaped histories and stepping-stone landscapes

This study evaluates qpAdm's performance on complex admixture histories and stepping-stone landscapes, finding high false discovery rates and suggesting protocol improvements.

A likelihood-based framework for demographic inference from genealogical trees

This paper introduces a likelihood-based framework called gLike to infer demographic history from genealogical trees, showing improved accuracy in estimating population parameters compared to existing methods.

Patterns of population structure and genetic variation within the Saudi Arabian population

This study analyzes genetic variation in Saudi Arabians, identifying sub-clusters and patterns influenced by demographic and cultural factors, and finds enrichment of deleterious alleles in more inbred sub-populations.

Testing Times: Challenges in Disentangling Admixture Histories in Recent and Complex Demographies

This study evaluates the performance of qpAdm and f3-statistic in admixture inference under historical and ancient DNA conditions, showing limitations in resolving fine-scale hypotheses but potential for improvement with better f-statistic methods.

The Complete Sequence and Comparative Analysis of Ape Sex Chromosomes

The paper produces gapless assemblies of ape sex chromosomes for five great apes and a lesser ape, revealing divergence in Y chromosomes and evolutionary dynamics.

The European Neolithic Expansion: A Model Revealing Intense Assortative Mating and Restricted Cultural Transmission

This study models the Neolithic expansion in Europe, finding limited cultural transmission and predominant within-group mating, challenging assumptions about demic diffusion.

CATE: A fast and scalable CUDA implementation to conduct highly parallelized evolutionary tests on large scale genomic data.

CATE accelerates evolutionary genomic tests using GPU and CPU parallelization, achieving over 180x speedup compared to standard tools.

Admixture has obscured signals of historical hard sweeps in humans

The paper shows that admixture in modern European genomes has masked over 50 historic hard sweeps, suggesting underappreciation of historical selection in human evolution.

Population genetic models of GERP scores suggest pervasive turnover of constrained sites across mammalian evolution

The paper evaluates how GERP scores relate to purifying selection and functional turnover across mammalian evolution, finding that 4.51% of noncoding human genome is under purifying selection with significant selection coefficient changes.

Understanding the Hidden Complexity of Latin American Population Isolates

The paper analyzes genomic diversity in Latin American population isolates, finding increased genetic diversity and consanguinity compared to the Finnish isolate.

Gene expression drives the evolution of dominance

The paper uses population genomic data to characterize the degree of dominance for new mutations and develops a new theory for its evolution.