This study shows that influenza A infection accelerates the formation of disease-associated microglia in aging mice, with effects observed in white matter regions.

bioRxiv · Dec 14, 2025 · PreprintNeuroscience

Deciphering Distinct Genetic Risk Factors for FTLD-TDP Pathological Subtypes via Whole-Genome Sequencing

Cyril P. Pottier, Fahri Küçükali, Matt C. Baker, Anthony J. Batzler, Gregory D. Jenkins, Marka van Blitterswijk, Cristina T. Vicente, Wouter De Coster, Sarah Wynants, Pieter Van de Walle, Owen A. Ross, Melissa Erin Murray, Júlia Faura, Stephen J. Haggarty, Jeroen van Rooij, , Edward B. Lee

This study identifies genetic risk factors for FTLD-TDP subtypes using whole-genome sequencing and meta-analysis across multiple cohorts.

Nature Communications · Apr 25, 2025Peer-reviewedGenetic & Genomic Medicine

The genetics of TDP43-Type-C neurodegeneration: a whole genome sequencing study

Malik M. Nassan, Iván Alejandro De León Ayala, Jennifer Sloan, Anna Bonfitto, Bobbi Stark, Serena Song, Marcus Naymik, Changiz Geula, Tamar D. Gefen, Elena Barbieri, Ignazio Stefano Piras, Marsel M. Mesulam, Matthew J. Huentelman

This study uses whole genome sequencing and AI to identify genetic variants associated with TDP43-Type-C neurodegeneration, finding novel links to FIG4, UBQLN2, INPP5A, and ANXA11.

medRxiv · Jan 25, 2025 · PreprintGenetic & Genomic Medicine