Rogan A. Grant

ExPert infers causal perturbations from cell states by learning prototypes across 12 contexts, achieving high recall with low compute and validating findings in disease models.

This study identifies and characterizes splenic macrophage subsets in mouse and human, revealing their ontogeny, dynamics, and age-related changes.

This study shows that influenza A infection accelerates the formation of disease-associated microglia in aging mice, with effects observed in white matter regions.

This study shows metformin lowers blood glucose by inhibiting intestinal mitochondrial complex I, increasing lactate and GDF15, and promoting glucose uptake.

This study identifies tissue-resident skeletal muscle macrophages that support muscle recovery from viral pneumonia in aging mice, with Mertk playing a key role.

The paper examines alveolar T cell responses in SARS-CoV-2 pneumonia patients, finding that early interferon signaling and targeting of structural proteins correlate with better clinical outcomes.

This study identifies NHR-49 as a regulator of stress resilience and proteostasis in C. elegans, linking lipid homeostasis to proteotoxic stress responses.

The paper identifies a systemic age-dependent transcriptome imbalance driven by transcript length across multiple species and shows its correlation with splicing factors and environmental stressors.