Melissa Erin Murray

The paper analyzes somatic mutations in neurons from FTLD-TDP type C patients and controls, finding extensive low-frequency variants in TARDBP and other genes.

This study identifies TDP-43 dysfunction as a cause of cryptic circular RNA formation in ALS/FTD, showing their association with disease-relevant protein loss and potential as biomarkers.

This study uses targeted proteomics to identify protein expression differences in Alzheimer's disease cases with varying clinical and neuropathological features.

The paper decouples TDP-43 and Tau pathology in Alzheimer's disease by analyzing transcriptomic profiles and identifies subtype-specific transcriptional signatures.

The paper identifies epigenetic changes in Alzheimer's disease brains linked to tau pathology, highlighting oligodendrocyte gene perturbations as a potential common mechanism across tauopathies.

The paper develops a tangle maturity scale to evaluate Alzheimer's disease pathology using tau antibodies and machine learning, showing early tau modifications precede advanced ones.

This study identifies genetic risk factors for FTLD-TDP subtypes using whole-genome sequencing and meta-analysis across multiple cohorts.

This paper introduces ProPPr, a method for proteomic profiling of phospho-tau aggregates in tauopathies, revealing common and disease-specific proteins associated with these lesions.

The paper identifies cell type-specific molecular changes in the prefrontal cortex of C9orf72 ALS/FTD patients correlated with pTDP-43 levels.

This study identifies differentially expressed genes and pathways in Alzheimer's disease brain tissue from African American donors, highlighting potential targets for treatment.

This study investigates changes in the UFMylation pathway in Alzheimer's disease brains, finding increased UFM1 conjugation and associations with pathological tau.

This study uses spatial proteomics to identify subregion-dependent protein changes in dementia variants, revealing disease-specific patterns in cortical layers and white matter.

The paper creates a single-cell atlas of the human primary motor cortex in ALS and FTLD, identifying transcriptional changes and molecular similarities between Betz cells and VENs.

The paper analyzes bulk RNA-seq data from diverse ethnic groups to identify differentially expressed genes and pathways in Alzheimer's Disease, highlighting cross-ethnic and ethnic-specific findings.

The paper identifies six genetic loci associated with Alzheimer's disease in Hispanics, showing both genetic and epigenetic risks, with some downstream effects on mRNA expression being ethnicity-specific.

This study performs a genome-wide association study of brain biochemical phenotypes in Alzheimer's patients, identifying novel genetic loci and highlighting distinct genetic architectures for AD-related proteins.

The paper characterizes phosphorylated tau fluid biomarker sites in postmortem Alzheimer's disease brains, showing they correspond to earlier neurofibrillary tangle maturity levels.

The paper uses single nucleus RNA sequencing to analyze brain vascular cells in Alzheimer's disease, identifying molecular changes and interactions between vascular and astrocytic cells at the blood-brain barrier.

This study identifies JADE1 as a novel genetic factor in tauopathy through genome-wide association and functional validation in human and Drosophila models.

The paper identifies SERPINA5 as a novel tau binding partner in Alzheimer's disease by analyzing hippocampal gene expression and neurofibrillary tangles.

This paper identifies a complex involving HNRNPA2B1, N6-methyladenosine modified transcripts, and toxic tau oligomers that mediates neurodegeneration.