Mridula Nambiar

Molecular mechanism for the functional divergence between cohesin paralogs during meiosis

This study identifies the molecular mechanisms that distinguish meiotic cohesin paralogs from their mitotic counterparts in Schizosaccharomyces pombe, showing why mitotic proteins cannot fulfill meiotic functions.

Meiotic cohesin paralogs govern cell survival by exhibiting flexibility in partner choice

This study shows meiotic cohesin paralogs can form hybrid complexes with mitotic subunits in somatic cells, affecting cell survival and genomic stability.

Centromere-proximal crossovers disrupt proper homologous chromosome disjunction during meiosis

This study shows that increased centromere-proximal crossovers cause meiotic nondisjunction and biorientation in S. pombe, supporting the entanglement model and highlighting mechanisms of aneuploidy.