Jean‐Marc Rolain

Bacterial NDH-1 is a key gut target of metformin mediating its antidiabetic effects

This study identifies bacterial NDH-1 as a target of metformin, showing it inhibits bacterial growth and carbohydrate fermentation, with implications for metformin's antidiabetic effects.

Global lessons from antibiotic resistance: metformin-hydrolyzing genes in transposable elements, a new threat for type II diabetic patients?

The paper investigates how metformin-degrading genes in transposable elements pose a new threat by co-selecting antibiotic resistance genes in environmental bacteria, endangering type II diabetic patients.

Methyltransferases in Candidate Phyla Radiation: A Weapon or a Simple Shield?

The paper investigates methyltransferases (MTs) in CPR genomes, finding they are primarily associated with restriction-modification systems for DNA defense and nucleotide scavenging rather than antimicrobial resistance.

Massive analysis of 64’628 bacterial genomes to decipher a water reservoir and origin of mobile colistin resistance (mcr) gene variants: is there another role for this family of enzymes?

The paper analyzes 64,628 bacterial genomes to identify the reservoir and origin of mcr gene variants, finding widespread presence in environmental bacteria, particularly in water sources.