Dylan T. Murray

Solid state NMR characterization of wild-type and mutant GFAP intermediate filament assemblies

This study uses solid state NMR to analyze wild-type and mutant GFAP filament assemblies, revealing structural differences caused by a mutation linked to Alexander disease.

ALS mutations in the TIA1 RNA granule protein have differing effect on low complexity domain fibril formation

The paper examines how ALS-linked mutations in TIA1's low complexity domain affect fibril formation and structural conformations in stress granules.

Phosphorylation Mimicking Mutations Cause TDP-43 to Adopt Different Fibril Conformations

This study shows that phosphomimetic mutations in TDP43LC alter fibril conformation during aggregation, despite similar soluble structures.

Metal ion binding of vimentin tail domain fragments

This study investigates the structural and metal binding properties of vimentin tail domain fragments, revealing direct Cu(II) binding to specific regions and providing insights into their role in vimentin function.

Small heat shock protein HSPB8 interacts with a pre-fibrillar TDP43 low complexity domain species to delay fibril formation

This study shows HSPB8 interacts with TDP43's low complexity domain to delay fibril formation without affecting elongation rates.

The Potent PHL4 Transcription Factor Effector Domain Contains Significant Disorder

This paper characterizes the disordered structure of the PHL4 transcription factor's effector domain and shows it forms a tetramer with a central folded region.

Cryo-EM and Solid State NMR Together Provide a More Comprehensive Structural Investigation of Protein Fibrils

This study combines cryo-EM and solid state NMR to better understand the structure of Tm1-LC fibrils, showing how each technique complements the other in revealing molecular conformations.