Understanding the mechanisms underlying the lack of response to Janus kinase inhibition in ulcerative colitis
Elisa Melón-Ardanaz, Marisol Veny, Ana Maria Corraliza, Victòria Gudiño, Alba Garrido-Trigo, Ángela Sanzo-Machuca, Marc Buendia, Miriam Esteller, Lisseth Robbins, Maria Teresa Rodrigo‐Calvo, Maria Carme Masamunt, Angel Giner, Marta Gallego, Íngrid Ordás, Agnes Fernandez-Clotet, , Azucena Salas
The paper investigates resistance to JAK inhibitors in UC by analyzing single-cell RNA data from responders and non-responders, identifying hyperactivation of myeloid cells as a key mechanism.
Journal of Crohn s and Colitis · May 5, 2025Peer-reviewedImmunology