Author

Leslie Donoghue Seeley

University of Alabama at BirminghamORCID 0000-0002-2408-3643Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cell Biology· 2

Signature Assays, Organisms & Methods

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Research Focus:cell signaling & trafficking· 2 Organism:human· 2 Approach:microscopy & imaging analysis· 2 Assay:fluorescence / live-cell microscopy· 1 Assay:imaging· 1

Frequent Co-Authors

Alexa L. MattheysesiD· 2 shared Collin M. AinslieiD· 1 shared Jie YuaniD· 1 shared Mary Kathryn Sewell-LoftiniD· 1 shared Tomasz J. NawaraiD· 1 shared Yen T. B. TraniD· 1 shared

Activity by Year

2026-2026 · peak 2/yr

Co-Author Collaboration Network

6 top collaborators · 9 mutual co-author links

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2 shared papersCell Biology

Alexa L. MattheysesORCID

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2 papers

Recent·Most cited

Cell BiologybioRxivPreprintJun 24, 2026

Fluid shear stress has a biphasic effect on clathrin-mediated endocytosis in vascular endothelial cells

Jie Yuan, Tomasz J. Nawara, Leslie Donoghue Seeley…·Alexa L. Mattheyses

This study shows fluid shear stress increases clathrin-mediated endocytosis in endothelial cells at low stress but not high stress.

DOI 10.64898/2026.06.23.734037

humanfluorescence / live-cell microscopy

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Cell BiologyJournal of Investigative DermatologyPeer-reviewedApr 30, 2026

Super-Resolution Imaging Reveals Stretch-Induced Architectural Rearrangement of Desmoplakin in Desmosomes

Leslie Donoghue Seeley, Collin M. Ainslie, Mary Kathryn Sewell-Loftin, Alexa L. Mattheyses

This study uses super-resolution imaging to show that mechanical stretch increases the distance between desmoplakin cytoplasmic tails in desmosomes, indicating a conformational shift in response to stress.

2 citations

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