Collin M. Ainslie

This paper identifies a reversible conformational change in the desmoplakin hinge domain in response to mechanical force, showing its role in mechanotransduction within desmosomes.

The paper shows N-cadherin is orientationally ordered at low mechanical load cardiomyocyte junctions but disordered at high load, indicating adaptation to local force conditions.

This study uses super-resolution imaging to show that mechanical stretch increases the distance between desmoplakin cytoplasmic tails in desmosomes, indicating a conformational shift in response to stress.

The paper investigates the architectural arrangement of desmoplakin isoforms in desmosomes using dSTORM and shows that tail domain position correlates with rod length.