Mark Verheul

This study evaluates the impact of an individual-specific pangenome on somatic variant calling in a pediatric AML patient, finding reduced false positives and altered phylogenetic branching.

This study uses single-cell whole-genome sequencing to show that Burkitt lymphoma develops through convergent evolution, with early genetic diversity and accelerated mutation accumulation.

The paper introduces PTATO, a bioinformatic workflow for detecting somatic mutations in single-cell WGS data using PTA, achieving high sensitivity for base substitutions and indels.

The paper introduces an updated R/Bioconductor package for analyzing mutational patterns, demonstrating its ability to detect mutational signatures and their biological implications using simulated and real data.