Alexander S. Steemers

STEER-seq enables pooled single-cell perturbation screening in hiPSCs by using defined genomic integration and barcode tracking to study transcription factor effects on cell identity.

This study uses single-cell whole-genome sequencing to show that Burkitt lymphoma develops through convergent evolution, with early genetic diversity and accelerated mutation accumulation.

Genes2Genes aligns single-cell trajectories using a Bayesian DP framework, revealing gene-level mismatches and highlighting differences in T cell differentiation between in vitro and in vivo states.