Single-cell spatial transcriptomics of fixed, paraffin-embedded biopsies reveals colitis-associated cell networks
Elvira Mennillo, Madison L. Lotstein, Gyehyun Lee, Julian H. Hou, Vrinda Johri, Donna Leet, Christina A. Ekstrand, Jessica Tsui, Jun He, Uma Mahadevan, Walter L. Eckalbar, Ryan M. Gill, Christopher Bowman, David Yoonsuk Oh, Gabriela K. Fragiadakis, , Alexis J. Combes
This study develops an iSCST framework for FFPE biopsies, identifying colitis-associated cell networks and VDZ response signatures in IBD patients.
Journal of Clinical Investigation · Jun 9, 2026Peer-reviewedImmunology