Author

Ryan Feehan

University of KansasORCID 0000-0002-2435-671XUnclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Assay:protein structure· 3 Organism:bacteria (other)· 2 Approach:statistical model· 2 Research Focus:chromatin & epigenetic regulation· 1 Approach:comparative / phylogenetic analysis· 1 Research Focus:database / resource· 1 Approach:machine learning (classical)· 1 Research Focus:protein folding & dynamics· 1

Frequent Co-Authors

Joanna S.G. SluskyiD· 3 shared Matthew M. CopelandiD· 2 shared Meghan Whitney Franklin· 2 shared Alaa Khamis· 1 shared Daniel MontezanoiD· 1 shared Nir Ben-Tal· 1 shared Rachel KolodnyiD· 1 shared Samuel LimiD· 1 shared

Activity by Year

2018-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 26 mutual co-author links

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3 shared papersBioinformatics

Joanna S.G. SluskyORCID

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3 papers

Recent·Most cited

Counting strands in outer membrane beta-barrels

Samuel Lim, Tejaswi Nimmagadda, Alaa Khamis, Daniel Montezano, Ryan Feehan, Matthew M. Copeland, Joanna S.G. Slusky

The paper introduces an algorithm to accurately count strands in bacterial outer membrane beta-barrels, achieving 97% accuracy on 571,760 structures from AlphaFold2.

Biophysical Journal · Mar 10, 2026Peer-reviewedBioinformatics

MAHOMES II: A webserver for predicting if a metal binding site is enzymatic

Ryan Feehan, Matthew M. Copeland, Meghan Whitney Franklin, Joanna S.G. Slusky

The paper improves a method to predict enzymatic metal binding sites using machine learning and computationally generated structures, achieving high precision and recall.

Protein Science · Mar 14, 2023Peer-reviewedBioinformatics

Evolution of Environmentally-Enforced, Repeat Protein Topology in the Outer Membrane

Meghan Whitney Franklin, Sergey Nepomnyachiy, Ryan Feehan, Nir Ben-Tal, Rachel Kolodny, Joanna S.G. Slusky

The paper traces the evolutionary pathway of outer membrane beta barrels, showing how repeat protein topology evolves through strand number changes without domain duplication, driven by membrane environment constraints.

bioRxiv · Apr 27, 2018 · PreprintBiophysics