Author

Rui‐Xue Leng

Anhui Medical UniversityORCID 0000-0002-2453-5865Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Genetic & Genomic Medicine· 1 Molecular Biology· 1 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Organism:human· 2 Organism:mouse· 2 Approach:statistical model· 2 Approach:deep learning· 1 Research Focus:drug response / drug discovery· 1 Research Focus:GWAS / association mapping· 1 Assay:GWAS summary statistics· 1 Assay:proteomics· 1

Frequent Co-Authors

Jianping WengiD· 2 shared Suowen XuiD· 2 shared Zhihua WangiD· 2 shared Akari SuzukiiD· 1 shared Bong-Jo KimiD· 1 shared Bradford C. BerkiD· 1 shared Chang‐Hee SuhiD· 1 shared Changbing SheniD· 1 shared

Activity by Year

2020-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 19 mutual co-author links

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Focal author (center)Selected co-authorORCID co-authorUnlinked name

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2 shared papersPharmacology & Toxicology

Jianping WengORCID

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3 papers

Recent·Most cited

Neratinib, a clinical drug against breast cancer, protects against atherosclerosis via ASK1 inhibition

Fan-shun Zhang, Chenyang He, Yanjun Yin, Zhihua Wang, Xiumei Wu, Danielle Kamato, Ruixue Leng, Jiang‐Yun Luo, Jianping Weng, Suowen Xu

Neratinib reduces atherosclerosis by inhibiting ASK1-mediated endothelial inflammation, showing potential as a repurposed drug for vascular disease.

Circulation Research · Jan 9, 2026Peer-reviewedPharmacology & Toxicology

Endothelial MICU1 protects against vascular inflammation and atherosclerosis by inhibiting mitochondrial calcium uptake

Lu Sun, Rui‐Xue Leng, Monan Liu, Meiming Su, Qingze He, Zhidan Zhang, Zhenghong Liu, Zhihua Wang, Hui Jiang, Li Wang, Shuai Guo, Yiming Xu, Yuqing Huo, Clint L. Miller, Maciej Banach, , Jianping Weng

This study shows that endothelial MICU1 prevents vascular inflammation and atherosclerosis by maintaining mitochondrial calcium homeostasis and reducing mitochondrial reactive oxygen species.

Journal of Clinical Investigation · Apr 1, 2025Peer-reviewedMolecular Biology

Meta-analysis of 208,370 East Asians identifies 113 genomic loci and yields new non-immune cell relevant biological insights for systemic lupus erythematosus

Xianyong Yin, Kwang-Woo Kim, Hiroyuki Suetsugu, So‐Young Bang, Leilei Wen, Masaru Koido, Eunji Ha, Lu Liu, Yuma Sakamoto, Sungsin Jo, Rui‐Xue Leng, Nao Otomo, Viktoryia Laurynenka, Young-Chang Kwon, Yujun Sheng, , Sang‐Cheol Bae

This study identifies 113 genomic loci for SLE in East Asians, including 46 novel loci, and highlights non-immune cell-related biological mechanisms.

Annals of the Rheumatic Diseases · Dec 3, 2020Peer-reviewedGenetic & Genomic Medicine