Bradford C. Berk

Tirzepatide attenuates atherosclerosis through weight loss-independent anti-inflammatory mechanisms

This paper shows tirzepatide reduces atherosclerosis independently of weight loss by directly targeting vascular inflammation through the cAMP/PKA/eNOS pathway.

Endothelial cell RpL17-dependent translational control mediates intima-media thickening in response to disturbed flow

This study shows that reduced RpL17 in endothelial cells under disturbed flow increases intima-media thickening by altering translational efficiency and causing ER stress and inflammation.

Re-evaluating the Impact of Biological Sex on Atherosclerosis in Apoe-/- and Ldlr-/- mice

This study evaluates the impact of biological sex on atherosclerosis in Apoe-/- and Ldlr-/- mice, finding sex-dependent differences in plaque burden and metabolic parameters.

PDE10A Inhibition Disrupts Lipid Droplet Formation and Sensitizes Macrophages to Ferroptosis after LPS treatment

This study shows that PDE10A inhibition reduces lipid droplet formation and increases macrophage susceptibility to ferroptosis after LPS treatment.

PDE10A Inhibition Reduces NLRP3 Activation and Pyroptosis in Sepsis and Nerve Injury

This study shows that PDE10A inhibition reduces NLRP3 inflammasome activation and pyroptosis in sepsis and nerve injury models, with potential for clinical application.

Endothelial MICU1 protects against vascular inflammation and atherosclerosis by inhibiting mitochondrial calcium uptake

This study shows that endothelial MICU1 prevents vascular inflammation and atherosclerosis by maintaining mitochondrial calcium homeostasis and reducing mitochondrial reactive oxygen species.

Spinal Cord Injury Enhances Lung Inflammation and Exacerbates Immune Response After Acute Lung Injury

This study shows that low-level spinal cord injury increases lung inflammation and immune response after LPS exposure, with heightened macrophage activity.