Zhihua Wang

This paper shows tirzepatide reduces atherosclerosis independently of weight loss by directly targeting vascular inflammation through the cAMP/PKA/eNOS pathway.

This study identifies desert hedgehog (DHH) as a resilience factor that prevents atherosclerosis by inhibiting PAI-1 signaling and endothelial mesenchymal transition.

Neratinib reduces atherosclerosis by inhibiting ASK1-mediated endothelial inflammation, showing potential as a repurposed drug for vascular disease.

The paper identifies self-reactive B cells in atherosclerosis-associated tertiary lymphoid organs that produce high-affinity autoantibodies contributing to disease progression.

This study shows that endothelial MICU1 prevents vascular inflammation and atherosclerosis by maintaining mitochondrial calcium homeostasis and reducing mitochondrial reactive oxygen species.

This study shows halofuginone, an FDA-approved drug, reduces obesity in mice by increasing FGF21 and GDF15 levels, improving metabolic health.