Author

Timothy En Haw Chan

Deutsches Konsortium für Translationale KrebsforschungORCID 0000-0002-2456-9336Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cancer Biology· 2

Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 2 Organism:human· 2 Approach:statistical model· 2 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1 Research Focus:gene regulatory network inference· 1

Frequent Co-Authors

H. T. Marc TimmersiD· 2 shared Md Saiful Islam· 1 shared Omid FotouhiiD· 1 shared Sheikh NizamuddiniD· 1 shared Stefanie Koidl· 1 shared

Activity by Year

2026-2026 · peak 2/yr

Co-Author Collaboration Network

5 top collaborators · 10 mutual co-author links

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2 shared papersCancer Biology

H. T. Marc TimmersORCID

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2 papers

Recent·Most cited

MLL4/KMT2D mutations increase immune activity and predict therapyefficacy in colorectal cancer

Timothy En Haw Chan, H. T. Marc Timmers

This study shows that KMT2D mutations in colorectal cancer are linked to increased immune activity and better response to immunotherapy and cisplatin.

bioRxiv · Aug 3, 2026 · PreprintCancer Biology

SMAD4 MH2 Mutations Disrupt CREBBP/EP300 Recruitment and TGF-β-Induced Transcription in Colorectal Cancer

Md Saiful Islam, Sheikh Nizamuddin, Timothy En Haw Chan, Omid Fotouhi, Stefanie Koidl, H. T. Marc Timmers

This study shows that SMAD4 MH2 mutations in colorectal cancer impair CREBBP/EP300 recruitment and TGF-β-induced transcription, explaining their loss-of-function effects.

bioRxiv · Jul 1, 2026 · PreprintCancer Biology