Cancer BiologybioRxivPreprint
SMAD4 MH2 Mutations Disrupt CREBBP/EP300 Recruitment and TGF-β-Induced Transcription in Colorectal Cancer
Md Saiful Islam, Sheikh Nizamuddin, Timothy En Haw Chan…·H. T. Marc Timmers
This study shows that SMAD4 MH2 mutations in colorectal cancer impair CREBBP/EP300 recruitment and TGF-β-induced transcription, explaining their loss-of-function effects.
DOI 10.64898/2026.06.30.735541