Molecular BiologyMolecular Therapy — Nucleic AcidsPeer-reviewed
Non-targeting control for MISSION(R) shRNA library silences SNRPD3 leading to cell death or permanent growth arrest
Maria Czarnek, Katarzyna Sarad, Agnieszka Karaś…·Joanna Bereta
The paper shows that a non-targeting shRNA control (SHC016) from the MISSION library causes cell death or growth arrest by targeting SNRPD3, highlighting off-target effects in RNAi studies.