Non-targeting control for MISSION(R) shRNA library silences SNRPD3 leading to cell death or permanent growth arrest
Maria Czarnek, Katarzyna Sarad, Agnieszka Karaś, Jakub A. Kochan, Joanna Bereta
The paper shows that a non-targeting shRNA control (SHC016) from the MISSION library causes cell death or growth arrest by targeting SNRPD3, highlighting off-target effects in RNAi studies.
Molecular Therapy — Nucleic Acids · Sep 14, 2021Peer-reviewedMolecular Biology