Macarena Fuentes‐Guajardo

The paper conducts a genome-wide association study in a Chilean admixed population to identify genetic loci associated with COVID-19 severity and susceptibility, finding four new loci.

The paper describes the establishment of the Chilean COVID-19 Biorepository, a multicenter initiative collecting multi-omics data from a Latin American population to study COVID-19 and long-COVID, with high-quality samples and data.

This study identifies loci under selection in Latin American admixed populations, distinguishing between pre- and post-admixture selection, and finds signals related to immunity and energy metabolism.

The paper evaluates prediction accuracy for eye, hair, and skin pigmentation in admixed Latin Americans using genomic and phenotypic data, finding that Random Forest and regression perform best, and that pigmentation SNPs improve accuracy, especially for skin color.

The paper analyzes ancestry in Latin Americans using haplotype-based methods, finding widespread Converso ancestry and links between Native ancestry and facial features.