Pharmacology & ToxicologybioRxivPreprint
Structural basis of MK-97 positive allosteric modulation at the M4 mAChR
Michaela G. Kaoullas, Jesse I. Mobbs, Ziva Vuckovic…·David M. Thal
This paper reports the cryo-EM structure of the M4 mAChR bound to MK-97 and acetylcholine, revealing how MK-97's binding mode improves PAM activity through distributed interactions.
DOI 10.64898/2026.05.06.723386