Keya Joshi

The paper investigates how specific stalk-derived peptides can reactivate signaling in disease-associated PC1 mutants and uses computational simulations to support these findings.

This paper reports the cryo-EM structure of the M4 mAChR bound to MK-97 and acetylcholine, revealing how MK-97's binding mode improves PAM activity through distributed interactions.

This study uses Pep-GaMD simulations to reveal how a tethered agonist transitions from a β-strand to a U-shaped helical configuration upon binding to ADGRD1.

The paper presents a cryo-EM structure of the M5 mAChR with a novel allosteric binding site identified through mutagenesis, pharmacology, and simulations.

This study uses PPI-GaMD simulations to reveal dynamic mechanisms of peptide agonist dissociation and deactivation in ADGRG1 and ADGRG2.

This study identifies stalk-derived peptides that activate PC1 signaling by binding to specific regions, revealing structural dynamics and potential therapeutic applications for ADPKD.