Xiangeng Wang

Alternative splicing expands and remodels the breast cancer proteoform landscape

The paper develops 3DisoGalaxy to study alternative splicing in breast cancer, finding that many transcripts produce translation-supported proteins and that functional divergence is concentrated in specific regions.

Structure-aware protein function prediction at isoform resolution

This study develops a framework for predicting protein function and domain annotation at isoform resolution using structural and sequence data, showing strong performance in benchmark tests and capturing domain changes across isoforms.

T4SE-XGB: interpretable sequence-based prediction of type IV secreted effectors using eXtreme gradient boosting algorithm

This study introduces T4SE-XGB, an XGBoost-based model for predicting type IV secreted effectors from protein sequences, achieving high accuracy and interpretability.

DTI-CDF: a CDF model towards the prediction of DTIs based on hybrid features

DTI-CDF improves drug-target interaction prediction by integrating hybrid features into a cascade deep forest model, achieving higher performance than existing methods.