Author

Yang Zhang

Baylor College of MedicineORCID 0000-0002-2519-7263Unclaimed ORCID profile · follow to get notified of new preprints

Additional preprints under this name without ORCID

Yang Zhang9 papers · St. Jude Children's Research Hospital

Biology Disciplines

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Genomics· 1 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Organism:human· 2 Assay:whole-genome sequencing· 2 Approach:benchmark study· 1 Research Focus:benchmarking· 1 Approach:experimental assay· 1 Research Focus:variant calling· 1

Frequent Co-Authors

Chenghang Chuck ZongiD· 2 shared Hsu Chao· 2 shared Muchun NiuiD· 2 shared Richard A. GibbsiD· 2 shared Adrienne HellandiD· 1 shared Alexi M. RunnelsiD· 1 shared Azeet NarayaniD· 1 shared Carrie CibulskisiD· 1 shared

Activity by Year

2025-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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2 shared papersGenomics

Chenghang Chuck ZongORCID

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2 papers

Recent·Most cited

Benchmarking of duplex sequencing approaches to reveal somatic mutation landscapes

Yang Zhang, Vinay Viswanadham, Michail Andreopoulos, Dominik Głodzik, Ruolin Liu, Lovelace J. Luquette, Se‐Young Jo, Azeet Narayan, Muchun Niu, Lisa Anderson, Joseph Brew, Hsu Chao, Carrie Cibulskis, Guanlan Dong, Uday S. Evani, , Tim H. H. Coorens

This study benchmarks six duplex sequencing technologies to evaluate their performance in detecting somatic mutations across different genomic contexts and tissue types.

bioRxiv · Dec 15, 2025 · PreprintGenomics

Expanding the Genome in a Bottle Truth Set: Detection and Validation of Novel Low-frequency Variants Using High-accuracy NanoSeq

Yang Zhang, Hsu Chao, Muchun Niu, Christopher M Grochowski, Kavya Kottapalli, Sravya V Bhamidipati, Donna Marie Muzny, Richard A. Gibbs, Chenghang Chuck Zong, Harsha Vardhan Doddapaneni

The paper introduces NanoSeq-MBN, a method improving variant detection in whole-genome sequencing, expanding the GIAB truth set with novel low-frequency variants and enabling somatic variant benchmarking.

bioRxiv · Dec 6, 2025 · PreprintMolecular Biology