Author

Brett M. Garabedian

Scripps Research InstituteORCID 0000-0002-2526-0525Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 1 Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Organism:human· 1 Research Focus:protein folding & dynamics· 1 Assay:proteomics· 1

Activity by Year

2026-2026 · peak 1/yr

1 paper

Recent·Most cited

ImmunologybioRxivPreprintFeb 9, 2026

Sheddase Targeting Chimeras (SHEDTACs) catalyze membrane target proteolysis

Brett M. Garabedian

This paper introduces SHEDTACs, bispecific antibodies that use cell surface proteolysis to degrade membrane targets, showing effectiveness in depleting LAG3 and PD-1 on T cells.

DOI 10.64898/2026.02.06.703938

humanproteomics

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