Kirsten K. Ness

Neurometabolic correlates of accelerated aging and neurocognitive late effects in long-term survivors of pediatric hodgkin lymphoma and acute lymphoblastic leukemia

The paper examines neurometabolic correlates of accelerated aging and neurocognitive late effects in adult survivors of pediatric cancers using 1H MRS and cognitive tests.

Genome-wide association study meta-analysis identifies susceptibility loci informing Ewing sarcoma etiology and potential mechanisms of risk

This study identifies 14 susceptibility loci for Ewing sarcoma through a genome-wide association meta-analysis, revealing genetic interactions with somatic EWSR1::FLI1 fusions.

A novel CEST-based approach for reliably assessing skeletal muscle oxidative phosphorylation: OXCEST

This paper introduces OXCEST, a CEST MRI method to assess skeletal muscle oxidative phosphorylation, showing strong correlation with 31P-MRS measurements.

Germline variation in DNA damage repair genes in children with cancer: Unveiling SMARCAL1 as novel osteosarcoma predisposition gene

The paper identifies SMARCAL1 as a novel predisposition gene for osteosarcoma by analyzing germline variants in DNA damage repair genes across childhood cancer cases.

Trans-ancestral genetic study of diabetes mellitus risk in survivors of childhood cancer: a report from the St. Jude Lifetime Cohort and the Childhood Cancer Survivor Study

This study identifies novel diabetes risk loci in childhood cancer survivors using whole-genome sequencing and shows higher risk for African ancestry survivors with risk alleles.

Persistent Variations of Blood DNA Methylation Associated with Treatment Exposures and Risk for Cardiometabolic Outcomes among Long-term Survivors of Childhood Cancer: A Report from the St. Jude Lifetime Cohort

This study identifies DNA methylation sites associated with cancer treatments and mediates cardiometabolic risks in childhood cancer survivors.

Genome-wide association studies reveal novel locus with sex-/therapy-specific fracture risk effects in childhood cancer survivors

The paper identifies a novel genetic locus associated with fracture risk in childhood cancer survivors, with effects specific to sex and therapy, using genome-wide association studies.

Generalizability of "GWAS hits" in clinical populations: Lessons from childhood cancer survivors

The paper evaluates the generalizability of GWAS findings in childhood cancer survivors and finds limited replication of meta-GWAS hits in these populations.