The origin and molecular evolution of the mammalian liver cell architecture
Xuefei Yuan, Leticia Rodríguez-Montes, Bastienne Zaremba, Nils Trost, Céline Schneider, Julia Schmidt, Bianka Berki, David Ibberson, Evgeny V. Leushkin, Birgit Nickel, Miklós Palkovits, Richard W. Truman, Gregory S. Barsh, John J. Lees, Amir Fallahshahroudi, , Henrik Kaessmann
This study investigates the evolutionary origins and dynamics of liver cell architecture across mammals, revealing conserved zonation and rapid evolutionary turnover in zonated genes.
bioRxiv · Oct 14, 2025 · PreprintEvolutionary Biology