Henrik Kaessmann

This study uses deep learning to predict cis-regulatory effects of human-specific mutations across 305 tissues, revealing their role in gene expression evolution.

This study shows that Eomes regulates UBC differentiation and migration in mice, mirroring human UBC development, and highlights conserved molecular mechanisms in cerebellar development.

This paper creates a multi-omics atlas of human hindbrain development, revealing cellular diversity, regulatory programs, and disease relevance.

This study identifies conserved and diverged gene regulatory networks in mammalian cerebellum development using single-nucleus gene expression and chromatin accessibility data from six species.

This paper integrates five vertebrate single-cell multi-omic atlases to reveal a conserved cellular blueprint and dual evolutionary constraints underlying early brain conservation across vertebrates.

The paper identifies TE fragments with regulatory potential in cerebellar development across species and introduces a framework to analyze their contribution to gene regulation.

This study investigates the evolutionary origins and dynamics of liver cell architecture across mammals, revealing conserved zonation and rapid evolutionary turnover in zonated genes.

This paper introduces a new ribosome profiling protocol that is faster, cheaper, and more sensitive, enabling use with minimal RNA input.

This study identifies miR-2954 as a male-essential microRNA critical for avian sex chromosome dosage compensation, showing its role in balancing gene expression in males and females.

This study analyzes gene regulatory programs in primate gonads, finding shared and species-specific regulatory dynamics and candidate genes for sex development disorders.

This study uses single-cell and spatial transcriptomics to analyze shark telencephalon development, revealing ancient origins of basal progenitors and Cajal-Retzius cells in gnathostomes.

The paper uses single-cell technologies to show that large-scale chromosomal aberrations drive medulloblastoma initiation, while single-gene oncogenic events like MYC contribute to progression and therapy resistance.

The paper characterizes the avian pallium's cell types and evolution using single-cell and spatial transcriptomics, revealing conserved and divergent features across amniotes.

This study presents a single-nucleus RNA-sequencing atlas of the postnatal shark retina, identifying 22 cell types and providing insights into retinal evolution.

This study identifies cell-state plasticity as a driver of heterogeneity in Group 3/4 medulloblastomas, showing that transcription factor perturbation can redirect tumor cells along different differentiation trajectories.

This study maps the regulatory landscape of mouse cerebellum development using snATAC-seq, identifying cis-regulatory elements and their spatiotemporal dynamics.

The paper identifies developmental gene expression differences between humans and mammalian models, finding that half of human genes differ from their mouse orthologs in temporal trajectories, particularly for disease-related genes.

The paper identifies regulatory elements that have switched function between enhancers and promoters across mammalian species and shows how these changes may drive evolutionary innovations.