Nils Trost

This paper creates a multi-omics atlas of human hindbrain development, revealing cellular diversity, regulatory programs, and disease relevance.

This study identifies conserved and diverged gene regulatory networks in mammalian cerebellum development using single-nucleus gene expression and chromatin accessibility data from six species.

This study investigates the evolutionary origins and dynamics of liver cell architecture across mammals, revealing conserved zonation and rapid evolutionary turnover in zonated genes.

This study identifies miR-2954 as a male-essential microRNA critical for avian sex chromosome dosage compensation, showing its role in balancing gene expression in males and females.

This study analyzes gene regulatory programs in primate gonads, finding shared and species-specific regulatory dynamics and candidate genes for sex development disorders.

The paper characterizes the avian pallium's cell types and evolution using single-cell and spatial transcriptomics, revealing conserved and divergent features across amniotes.

This study maps the regulatory landscape of mouse cerebellum development using snATAC-seq, identifying cis-regulatory elements and their spatiotemporal dynamics.

This study shows that Ubx suppresses cellular plasticity by interacting with Pho to set lineage-specific repressive chromatin marks, stabilizing lineage commitment in Drosophila.

WEADE provides a web tool for integrated enrichment analysis and data exploration of genomic datasets, enabling comparison of experiments and visualization of functional interactions.

The paper identifies key regulatory mechanisms in Drosophila male stem cells and provides a public dataset and tool for analyzing stem cell gene networks.