Mukund Thattai

The paper models glycan synthesis in the Golgi apparatus to identify Pareto-optimal enzyme distributions that balance glycan yield and residence time trade-offs.

The paper models the evolutionary emergence of endomembrane compartments in proto-eukaryotes by simulating molecular regulator changes and finding punctuated shifts in compartment composition.

The paper quantifies how surface glycans reflect Golgi dysfunction in single cells using fluorescent lectin probes and a mathematical model.

The paper investigates the coexistence of self-compatible and self-incompatible alleles in a plant metapopulation using spatial rock-paper-scissors dynamics, finding that population structure and competitor fitness influence allele frequencies.

The paper resolves the paradox of glycan microheterogeneity by developing algorithmic compartments that convert inputs to unique outputs, and applies this to real glycan datasets.

This paper demonstrates efficient in vivo DNA-encoded digital archives for 3D and 4D information storage using Halobacterium salinarum, with improved durability through mineral salt preservation.