Author

Sean C. Lema

California Polytechnic State UniversityORCID 0000-0002-2564-8992Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Evolutionary Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Assay:DNA methylation· 1 Approach:experimental assay· 1 Research Focus:gene regulatory network inference· 1 Assay:whole-genome sequencing· 1

Frequent Co-Authors

Bruce J. TurneriD· 1 shared Christopher H. MartiniD· 1 shared David TianiD· 1 shared Jennifer M. GummiD· 1 shared Kevin P. Wilson· 1 shared Michael Schwemm· 1 shared Naomi Siu· 1 shared Nicolas M. AlexandreiD· 1 shared

Activity by Year

2026-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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1 shared paperEvolutionary Biology

Bruce J. TurnerORCID

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1 paper

Recent·Most cited

Long-term small effective population size, inbreeding, and a recessive lethal haplotype drive premature death in the endangered Devils Hole pupfish (Cyprinodon diabolis)

David Tian, Nicolas M. Alexandre, Naomi Siu, Vanessa Muhl, Sean C. Lema, Bruce J. Turner, Olin G. Feuerbacher, Kevin P. Wilson, Michael Schwemm, Priya Moorjani, Jennifer M. Gumm, Christopher H. Martin

The paper investigates how long-term small population size and inbreeding contribute to premature death in Devils Hole pupfish using genomic and phenotypic data.

bioRxiv · Jun 10, 2026 · PreprintEvolutionary Biology