Tumor cell-adipocyte gap junctions activate lipolysis and contribute to breast tumorigenesis
Jeremy Williams, Roman Camarda, Serghei Malkov, Lisa J. Zimmerman, Suzanne Manning, Dvir Aran, Andrew R. Beardsley, Daniel Van de Mark, Rachel M. Nakagawa, Yong Chen, Charles A. Berdan, Sharon M. Louie, Céline I. Mahieu, Daphne A. Superville, Juliane Winkler, , Andrei Goga
The paper shows that gap junctions between breast cancer cells and adipocytes transfer cAMP, activating lipolysis in the tumor microenvironment to support tumor growth.
Nature Communications · Aug 20, 2025Peer-reviewedCancer Biology