Macrophage-Derived 25-Hydroxycholesterol Drives Statin-Associated Acute Kidney Injury
Hye Jin Wang, Eun Jee Kim, Yuri Cho, Jung Ho Lee, Jongjin Yoon, Hye-Youn Kim, Youngrak Jung, Haebeen Lee, Hoon Young Choi, June-Yong Lee, Heon Yung Gee, Beom Seok Kim
This study shows that macrophage-derived 25-hydroxycholesterol increases susceptibility to statin-induced acute kidney injury by impairing autophagy and promoting cell death.
bioRxiv · Oct 22, 2026 · PreprintPharmacology & Toxicology