Heon Yung Gee

This study shows that macrophage-derived 25-hydroxycholesterol increases susceptibility to statin-induced acute kidney injury by impairing autophagy and promoting cell death.

The paper develops TAILVAR, a machine-learning classifier to predict the functional impact of stop-loss variants by integrating multi-omics features, and shows it outperforms existing tools.

This study introduces CM-SLP, a platform to identify non-oncology drugs that enhance cancer cell death under altered nutrient conditions by targeting metabolic vulnerabilities.

The paper introduces Korea10K, a large genomic dataset of 10,239 Korean genomes with multiomic and clinical data, enabling population-specific variant imputation and insights into genomic-epigenomic regulation.

The paper identifies rare missense variants in OTOP2 and MYO7A genes in a South Korean Meniere disease cohort, suggesting their potential pathogenic roles.

The paper identifies de novo mutations contributing to meningomyelocele risk by analyzing trios and finding damaging mutations in 22.3% of cases.

This study identifies TMEM145 as a critical transmembrane protein in OHC stereociliary structures, showing its necessity for structural integrity and auditory function.

This study shows that the adherent-to-suspension transition in melanoma cells enhances metastatic potential by reprogramming anchorage dependency, independent of epithelial-to-mesenchymal-like transition pathways.

The paper shows cell competition enables loser cells to gain metastatic potential through anchorage plasticity, mediated by AST factors, and demonstrates this in breast cancer metastasis.

This study identifies a novel WFDC2 mutation causing severe respiratory disease with features similar to cystic fibrosis and primary ciliary dyskinesia in Korean patients.

This study shows ADCK4 deficiency causes CoQ10 deficiency and mitochondrial dysfunction in podocytes, which is rescued by 2,4-dihydroxybenzoic acid treatment.

This paper uses whole-exome sequencing to identify genetic markers for hypouricemia and shows that screening two SNPs can detect 87.7% of cases.