Molecular Mechanisms Underlying Human Vγ9Vδ2 T Cell Activation by Butyrophilin-3 (BTN3) Targeted Antibodies
Bangdong Huang, Weizhi Xin, Wenjia Zhang, Weijie Gao, Yundi Hu, Yuehua Liu, Qiang Su, Qiang Zhou
This study identifies how ICT01 antibody activates Vγ9Vδ2 T cells by binding BTN3As, destabilizing BTN2A1-BTN3As interface, and promoting TCR engagement.
bioRxiv · Oct 21, 2025 · PreprintImmunology