Leon Martin

The Virtual Child Brain: Modeling Neuromaturational Trajectories

The paper develops a computational model to study human brain maturation by analyzing functional MRI data and simulating neural network dynamics.

Brain network modeling with The Virtual Brain derives pharmacodynamics of ketamine

This paper uses computational modeling to explore how ketamine's dose-dependent NMDAR antagonism affects brain dynamics across its full dose spectrum.

An Interactive Brain Atlas of Knowledge

The paper develops TVBase, a platform that projects biomedical knowledge onto a 3D brain atlas to support neuroimaging analysis and hypothesis generation.

The Virtual Brain Ontology: A Digital Knowledge Framework for Reproducible Brain Network Modeling

The paper introduces TVB-O, a framework to improve reproducibility and comparability of brain network simulations by standardizing metadata and enabling executable code generation.

Fast and Easy Whole-Brain Network Model Parameter Estimation with Automatic Differentiation

TVB-Optim enables efficient parameter estimation for whole-brain network models using automatic differentiation, achieving faster and more scalable optimization than traditional methods.

Biological Database Mining for LLM-Driven Alzheimer's Disease Drug Repurposing

This paper develops an LLM-driven pipeline for Alzheimer's drug repurposing by integrating ontologies and drug databases, showing improved alignment with expert knowledge and reduced hallucinations.

A multiscale closed-loop neurotoxicity model of Alzheimer's disease progression explains functional connectivity alterations

This paper develops a multiscale closed-loop model of Alzheimer's disease that links proteinopathy to electrophysiological changes, revealing causal relationships between Aβ and hp-tau depositions and neural activity alterations.