Leon Stefanovski

This paper uses computational modeling to explore how ketamine's dose-dependent NMDAR antagonism affects brain dynamics across its full dose spectrum.

The paper develops TVBase, a platform that projects biomedical knowledge onto a 3D brain atlas to support neuroimaging analysis and hypothesis generation.

This paper integrates the Larter-Breakspear model into a mouse brain connectome to study chaotic dynamics and ion-channel effects on network behavior.

The paper introduces TVB-O, a framework to improve reproducibility and comparability of brain network simulations by standardizing metadata and enabling executable code generation.

This paper develops an LLM-driven pipeline for Alzheimer's drug repurposing by integrating ontologies and drug databases, showing improved alignment with expert knowledge and reduced hallucinations.

This paper develops a multiscale closed-loop model of Alzheimer's disease that links proteinopathy to electrophysiological changes, revealing causal relationships between Aβ and hp-tau depositions and neural activity alterations.

This study models the differential effects of Amyloid-Beta and Tau on neuronal activity in Alzheimer's Disease, finding A{beta} dominance in early stages and Tau dominance in later stages.

This paper demonstrates a multiscale co-simulation approach combining a spiking basal ganglia model with a whole-brain mean-field model to predict the effects of virtual deep brain stimulation in Parkinson's disease.

The paper combines brain simulations with machine learning to improve dementia classification by integrating PET and MRI data with simulated electrophysiological features.

The paper demonstrates that each individual's brain has a converging optimal working point in The Virtual Brain model that predicts fMRI and EEG features, with inter-individual differences driven by structural connectivity.

The paper uses computational modeling to link molecular pathways with neural dynamics in Alzheimer’s disease, showing how Abeta burden affects brain activity and potential reversibility with memantine.