Andreas Horn

The SWAN atlas: an open multimodal resource combining neuroimaging and high-resolution histology of the human brain in stereotactic space

The paper presents the SWAN atlas, a multimodal resource combining neuroimaging and high-resolution histology of the human brain in stereotactic space to improve localization accuracy for clinical applications.

A precise atlas of the human subcortex

FOCUS, a 100 µm atlas of 180 manually segmented subcortical grey and white matter regions and 77 hand-built tracts, registered to MNI 2009b space for warping to individual brains.

Functional fractionation of large-scale brain networks in the human subcortex

This study identifies and characterizes fifteen subnetworks within subcortical brain regions, revealing their functional organization and potential applications in understanding neuropsychiatric disorders.

The methodological foundations of lesion network mapping remain sound

The paper defends lesion network mapping by showing that it provides meaningful differences through specificity testing, refuting criticisms that it reflects normative connectome properties.

An Interactive Brain Atlas of Knowledge

The paper develops TVBase, a platform that projects biomedical knowledge onto a 3D brain atlas to support neuroimaging analysis and hypothesis generation.

Subcortical Hubs of Brain Networks Sustaining Human Consciousness

This study identifies subcortical hubs connected to multiple cortical networks using rs-fMRI data, suggesting they are targets for restoring consciousness in disorders of consciousness.

Differential modulation of movement speed with state-dependent deep brain stimulation in Parkinson's disease

This study shows that state-dependent deep brain stimulation in Parkinson's disease increases movement speed more effectively during fast movements, using machine learning to decode brain signals for real-time adjustments.

Shared subcortical arousal systems across sensory modalities during transient modulation of attention

The paper investigates shared subcortical arousal systems across sensory modalities during attention modulation using fMRI data from 1,561 participants.

Shared pathway-specific network mechanisms of dopamine and deep brain stimulation for the treatment of Parkinson's disease

This study identifies how dopamine and deep brain stimulation affect cortex-basal ganglia networks at different scales, showing distinct mesoscale effects and shared macroscale suppression of network synchrony.

Lesions that Cause Psychosis Map to a Common Brain Circuit in the Hippocampus

This study identifies a common brain circuit in the hippocampus associated with psychosis caused by lesions, suggesting it as a target for neuromodulation.

Cortical beta oscillations map to shared brain networks modulated by dopamine

This study identifies a shared brain network modulated by dopamine that underlies beta oscillations, revealing their role in cortico-subcortical circuits beyond motor function.

Human hippocampal ripples tune cortical responses in uncertain visual contexts

The paper shows that hippocampal ripples predict visual stimulus unpredictability and modulate cortical responses in humans.

A Structural Connectivity Atlas of Limbic Brainstem Nuclei

The paper maps the structural connectivity of five brainstem nuclei to limbic cortical regions using MRI and tractography, creating a freely available atlas for future research.

Mapping the subcortical connectivity of the human default mode network

This paper maps subcortical connectivity of the human default mode network using rs-fMRI and a novel tensor decomposition method, identifying key subcortical regions correlated with the DMN.

A functional network target for tic reduction during thalamic stimulation for Tourette Syndrome

This study identifies functional connectivity patterns associated with tic reduction in Tourette Syndrome patients undergoing thalamic deep brain stimulation.

Electrocorticography is superior to subthalamic local field potentials for movement decoding in Parkinson's disease

This paper compares electrocorticography (ECoG) and subthalamic local field potentials (LFP) for movement decoding in Parkinson's disease, finding ECoG superior and demonstrating the impact of PD pathophysiology on decoding performance.

Toward a unified connectomic target for deep brain stimulation in obsessive-compulsive disorder

The paper identifies a common neural tract associated with treatment response in OCD patients undergoing DBS targeting different brain regions.

Neural signatures of pathological hyperdirect pathway activity in Parkinson's disease

The paper identifies signatures of the hyperdirect pathway and its role in pathological network disruption in Parkinson's disease through multimodal analysis.

Deep Brain Stimulation: Imaging on a group level

This paper introduces Lead Group, a tool for group-level DBS imaging analysis, showing optimal DBS targets in the dorsolateral STN and a fiber bundle linked to clinical outcomes in Parkinson's disease.

Left prefrontal impact links subthalamic stimulation with depressive symptoms

This study links left prefrontal connectivity with worsening depressive symptoms after STN-DBS in Parkinson's Disease.

7 Tesla MRI of the ex vivo human brain at 100 micron resolution

The paper presents an ultra-high resolution MRI dataset of an ex vivo human brain and provides it in both native and stereotactic spaces for research and educational use.

Directional DBS Leads Show Large Deviations from their Intended Implantation Orientation

The paper examines deviations in directional DBS lead orientation from intended implantation directions in a patient cohort.

Deep Brain Stimulation induced normalization of the human functional connectome in Parkinson’s Disease

This study uses resting-state fMRI to show that deep brain stimulation (DBS) in Parkinson’s Disease modulates global brain connectivity, normalizing it toward healthy controls and altering specific network couplings.

Connectivity profile of thalamic deep brain stimulation to effectively treat essential tremor

This study identifies effective deep brain stimulation targets for essential tremor by analyzing structural and functional brain connectivity in patients.

Lead-DBS v2: Towards a comprehensive pipeline for deep brain stimulation imaging

The paper updates the Lead-DBS pipeline for DBS imaging and connectomics, demonstrating its application on clinical data and comparing preprocessing strategies.

Toward defining deep brain stimulation targets in MNI space: A subcortical atlas based on multimodal MRI, histology and structural connectivity

The paper creates a composite atlas of subcortical brain structures for DBS targets using multimodal MRI, histology, and structural connectivity to improve electrode placement analysis.