Christian Porras

This study performs a single-nucleus transcriptome-wide association study to identify gene-trait associations in brain disorders, revealing cell-type-specific genetic regulation and ancestry-specific patterns.

The paper constructs a single-nucleus atlas of genetic regulation in the human brain, identifying cell-type-specific regulatory effects and disease-associated genes.

The paper profiles human myeloid cells across aging and Alzheimer's disease, identifies AD-associated changes, and links GPNMB to neuroprotection via TREM2.

This study creates a single-nucleus transcriptomic atlas of Parkinson's disease progression, identifying cell-type-specific gene expression changes and linking them to genetic risk factors and disease stages.

This paper investigates how geographic breadth of sampling affects the discovery and frequency of rare, deleterious variants in genetic studies.