James M. Vicari

Plasticity of Human Microglia and Brain Perivascular Macrophages in Aging and Alzheimer's Disease

The paper profiles human myeloid cells across aging and Alzheimer's disease, identifies AD-associated changes, and links GPNMB to neuroprotection via TREM2.

A genetically based computational drug repurposing framework for rapid identification of candidate compounds: application to COVID-19

This paper presents a computational drug repurposing framework that identifies FDA-approved drugs for COVID-19 by integrating genetic expression data and EMR data, finding four compounds with protective effects in validation.

Multi-omic profiling of the developing human cerebral cortex at the single cell level

The paper profiles gene expression and chromatin accessibility in 45,549 cortical nuclei across 6 developmental timepoints to study cell fate determination and neuropsychiatric disease mechanisms.

Novel small molecules inhibit proteotoxicity and inflammation: Mechanistic and therapeutic implications for Alzheimer's Disease, healthspan and lifespan- Aging as a consequence of glycolysis

The paper identifies small molecules that inhibit proteotoxicity and inflammation in Alzheimer's Disease models, revealing mechanisms linking glycolysis to neuroinflammation and suggesting new therapeutic targets.

The three-dimensional landscape of chromatin accessibility in Alzheimer's disease

This study maps chromatin accessibility in Alzheimer's disease using ATAC-seq, identifying regulatory changes and 3D genomic alterations linked to disease.

Population-level variation of enhancer expression identifies novel disease mechanisms in the human brain

The paper identifies population-level variation in enhancer expression in the human brain and links enhancer eQTL to schizophrenia heritability.

IL10RB as a key regulator of COVID-19 host susceptibility and severity

The paper identifies IL10RB as a key regulator of COVID-19 host susceptibility and severity through integrative analysis of genetic and transcriptomic data, and validates potential drug repositioning candidates.